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KMID : 0367020100220010080
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Journal of Korean Academic of Adult Nursing
2010 Volume.22 No. 1 p.80 ~ p.89
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Study of Subclinical Thyroid Function Disorder and the Risk of Coronary Artery Disease in Women
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Yeoum Soon-Gyo
Park Chai-Soon
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Abstract
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Purpose: This paper has attempted to investigate the association between the subclinical thyroid function disorder caused by natural change in thyroid hormones or thyroid remedies and the incidence of CHD.
Methods: Data was analyzed of 7,675 women who had undergone health examinations in a hospital in Gyeonggi-do between January 2007 and December 2008. The covariation of the coronary risk factors such as age, BMI, HbA1C, systolic blood pressure, LDL:HDL-cholesterol ratio, CRP, smoking and exercise were analyzed by using logistic regression analysis.
Results: A significant increase in serum TSH was observed with higher age(F=26.91, p=.00). In terms of age, the risk of CHD started to gradually increase since the 40s and sharply since the 60s( x2=113.29, p=.00). The serum TSH was the most significant parameter influencing CHD(B=.12, p=.00). The risk of coronary artery disease was 3.12 times higher in the subclinical hypothyroidism group(OR=3.12) while no significant difference was observed in the subclinical hyperthyroidism group.
Conclusion: Subclinical hypothyroidism may be an independent risk factors for CHD. A nurse nursing patients with thyroid disorder should be well informed of their state of subclinical thyroid function disorder and make efforts to extend their health expectancy.
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KEYWORD
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Thyroid hormone, Coronary artery disease
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